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Stephen Hawking's name came up in the newly unsealed Jeffrey Epstein documents. In 2015, Epstein offered to pay people to disprove an allegation that Hawking was in an "underage orgy." AdvertisementThere's been a lot of chatter about Stephen Hawking's name appearing in the newly unsealed Jeffrey Epstein documents — but has the renowned physicist been accused of anything? And the unsealed documents, from a civil lawsuit Giuffre filed against Maxwell in 2016, do not include any such allegations from Giuffre. The release involving Hawking was the first batch of documents unsealed.
Persons: Stephen Hawking's, Jeffrey Epstein, Epstein, Hawking, , There's, Ghislaine Maxwell, Maxwell, Virginia Giuffre, clinton, hawking, ted, Epstein bankrolled, Hawking hasn't, Giuffre, Bill Clinton, Clinton, Stephen Hawking Organizations: Service, New, Independent Locations: New York, Giuffre
Elon Musk's startup received FDA approval to start human trials earlier this year. The brain chip startup aims to implant a device that acts as a "Fitbit in your skull." NEW LOOK Sign up to get the inside scoop on today’s biggest stories in markets, tech, and business — delivered daily. AdvertisementAdvertisementThousands of people have expressed interest in receiving one of Neuralink's brain implants, according to a recent Bloomberg report from one of Elon Musk's biographers, Ashlee Vance. "They are currently kicking our ass," Musk said after Synchron implanted its first device in a US patient in July 2022.
Persons: , Elon Musk's, Ashlee Vance, Neuralink, Musk, Vance, Elon, Musk's, Synchron, That's, SpaceX's Organizations: Bloomberg, Elon Musk's, Service, US Food and Drug Administration, FDA, Reuters, SpaceX, YouTube Locations: Australia
Ambitious research yields new atlas of human brain cells
  + stars: | 2023-10-12 | by ( Will Dunham | ) www.reuters.com   time to read: +5 min
The human brain is complex in terms of its utility - sensing, moving, reading, writing, speaking, thinking and more - and its cellular diversity. The research identified 3,313 cell types, roughly 10 times more than previously known, and the complete set of genes used by each cell type while also mapping their regional distribution in the brain. "The brain cell atlas as a whole provides the cellular substrate for everything that we can do as human beings," said neuroscientist Ed Lein of the Seattle-based Allen Institute for Brain Science, one of the researchers. The various cell types have distinct properties and are likely affected differently in disease, Lein said. "We are only at the very beginning of delineating the complexity of the human brain," said another of the researchers, Bing Ren, director of the University of California, San Diego Center for Epigenomics.
Persons: Denis Balibouse, Ed Lein, Lein, Trygve Bakken, Bing Ren, Will Dunham, Rosalba O'Brien Organizations: Belle Idee University, REUTERS, Rights, U.S, government's National Institutes of Health, Census Network, Allen Institute for Brain Science, Allen, University of California, San Diego Center for Epigenomics, Thomson Locations: Neuropsychiatry, Chene, Bourg, Geneva, Seattle
CNN —Calgary Flames assistant general manager Chris Snow died on Saturday following his battle with ALS, his wife Kelsie Snow announced. “The National Hockey League family is deeply saddened by the passing of Calgary Flames Assistant General Manager Chris Snow, a remarkable man whose courageous and relentless battle with ALS has been an inspiration to so many,” NHL commissioner Gary Bettman said in a statement. Prior to his time with the Flames, Snow was a sports reporter for the Boston Globe, where he covered the Boston Red Sox, and the Minneapolis Star-Tribune, where he covered the Minnesota Wild. Following his time as a journalist, Snow worked as a director of hockey operations for the Wild from 2006 through 2010. He is survived by his wife Kelsie, his son Cohen, and his daughter Willa.
Persons: Chris Snow, Kelsie Snow, Chris, ” Snow, Lou Gehrig’s, “ Chris, Craig Conroy, Kelsie, Cohen, Willa, , Gary Bettman, Snow Organizations: CNN — Calgary Flames, ALS, Flames, ” Flames, National Hockey League, Calgary Flames, NHL, Club’s Hockey, Boston Globe, Boston Red Sox, Minneapolis Star, Tribune Locations: Minnesota
Signage is seen outside of the Food and Drug Administration (FDA) headquarters in White Oak, Maryland, U.S., August 29, 2020. Brainstrom's therapy, NurOwn, is being reviewed for the treatment of ALS, also known as Lou Gehrig's Disease, which affects nerve cells in the brain and spinal cord. The FDA had in November last year refused to accept the application for the therapy after BrainStorm failed to meet the main goal in a late-stage study. Over the last one year, the FDA has given accelerated approvals to Amylyx Pharmaceuticals' (AMLX.O) drug Relyvrio and Biogen's (BIIB.O) Qalsody for treatment of ALS. A panel of external advisors to the FDA is set to vote on the effectiveness of the therapy in ALS patients on Wednesday.
Persons: Andrew Kelly, Lou Gehrig's Disease, Amylyx, Mariam Sunny, Leroy Leo, Krishna Chandra Organizations: Food and Drug Administration, FDA, REUTERS, U.S . Food, Drug, Cell Therapeutics, Amylyx Pharmaceuticals, ALS Association, Thomson Locations: White Oak , Maryland, U.S, Bengaluru
Those advocates still face one giant hurdle: FDA regulators say the treatment hasn't been shown to work. But with the backing of thousands of ALS patients, Brainstorm took the rare step of “filing over protest,” essentially forcing the agency to render a decision. Still, ALS patients see reasons for optimism. At Wednesday’s meeting, people with such reservations are certain to be outnumbered by appeals from ALS patients and their families. That compromise would be similar to FDA's approach to Relyvrio last year, another ALS drug with questionable data.
Persons: Lou Gehrig’s, drugmaker, they’re, , Marc Scheineson, Brian Wallach, Wallach, , Brainstorm’s, NurOwn, Patricia Manhardt, Anthony Windebank, reanalyzing, weren’t, Terry Heiman, Patterson, it’s, Holly Fernandez Lynch, Matthew Perrone Organizations: WASHINGTON, Drug Administration, FDA, drugmakers, Congress, Obama White House, ALS Association, Mayo Clinic, Physicians, Temple University, University of Pennsylvania, Twitter, Associated Press Health, Science Department, Howard Hughes Medical Institute’s Science, Educational Media Group, AP
New York CNN —Elon Musk’s controversial biotechnology startup Neuralink opened up recruitment for its first human clinical trial Tuesday, according to a company blog. After receiving approval from an independent review board, Neuralink is set to begin offering brain implants to paralysis patients as part of the PRIME Study, the company said. In May, Neuralink tweeted that it had received FDA clearance for human clinical trials, with the approval acknowledged by the agency in a statement. Musk has forecast human trials at the startup at least four times since 2019, yet the company didn’t seek FDA approval until 2022. Before Neuralink’s brain implants hit the broader market, they’ll need regulatory approval.
Persons: New York CNN — Elon, Musk, Neuralink, Peter Thiel, Organizations: New, New York CNN, Founders Fund, PayPal, Twitter, Reuters, Food and Drug Administration, FDA Locations: New York, San Francisco, Neuralink
Elon Musk's neurotech startup Neuralink will begin recruiting patients for its first in-human clinical trial, the company announced in a blog post. Patients who participate in the trial will have to undergo invasive brain surgery. Neuralink is building a brain implant that aims to help people with severe paralysis control external technologies using only neural signals. As of September, no BCI company has managed to clinch the FDA's final seal of approval. But by receiving the go-ahead to recruit for a study with human patients, Neuralink is one step closer.
Persons: Elon, Neuralink, Musk, Tesla Organizations: Food and Drug Administration, SpaceX, BCI
Elon Musk's Neuralink is seeking candidates for its first human trials. Neuralink wants to test their brain chips on people with cervical spinal cord injuries or ALS. The company is under federal investigation for animal welfare abuses while conducting animal tests. At a company event last year, Musk said he would test Neuralink's brain chips on himself when human trials begin. AdvertisementAdvertisementNeuralink received approval from the Food and Drug Administration in May to embark on human trials.
Persons: Elon Musk's Neuralink, Neuralink, Musk, Organizations: Service, Food and Drug Administration, Reuters Locations: Wall, Silicon
CNN —A novel trial that has been described as “the last roll of the dice” for a generation of HIV vaccines has entered its latter stages. Nearly 40 years since HIV was identified as the cause of AIDS, and 36 years since the first HIV vaccine trial, the medical community still does not have a working vaccine. But that is not necessarily why they were chosen to participate, said Eugene Ruzagira, PrEPVacc trial director. Evaluating the combination of a trial HIV vaccine and PrEP is a first, say organizers. “I did my very first HIV vaccine trial in 1991,” recalled Weber.
Persons: PrEPVacc, , Jonathan Weber, Frank, Helena Herholdt, Eugene Ruzagira, Ruzagira, , Weber, ” Ruzagira, “ We’ve, Mark Runnacles, Edward Jenner, Louis Pasteur, Galileo, Win McNamee, Humphry Davy, JEAN, SEBASTIEN EVRARD, Haydn West, Joe Raedle, ANNE, CHRISTINE POUJOULAT, Alexander Fleming, Fleming, wasn't, Louise Joy Brown, Sandy Huffaker, Daniel Acker, James Watson, Francis Crick, Rosalind Franklin, Watson, Crick, Raphael GAILLARDE, Sean Gallup, Wilhelm Conrad Röntgen, Thomas Edison's, INDRANIL MUKHERJEE, Descovy, Luwano Geofrey, Dr, Luke Dray, Geofrey, Nishanta Singh, Sharon Lewin, Lewin, “ it’s, it’s, ” Lewin, ” Geofrey Organizations: CNN, Imperial College Academic Health Science Centre, PrEPVacc, Medical Research, Uganda Virus Research Institute, European Union, Smithsonian National Museum of, Cleveland Clinic, Volvo, Bayer, U.S . Food, Drug Administration, Getty, Keystone, — Farmers, Food and Drug Administration, FDA, Bloomberg, PANTHAKY, PrEP, US Centers for Disease Control, Independent, The University of Melbourne, International AIDS Society, Muhimbili University of Health, Allied Sciences, Dar Locations: Entebbe, Uganda, Thailand, London, Mbeya, Tanzania, South Africa, Ugandan, Durban, Masaka, Salam, African, Africa, China, FPG, AFP, United States, America, U.S, Peoria , Illinois, Europe, , Dar es Salaam, Rwanda
The 44-year-old man was surfing near Lighthouse Beach, Port Macquarie when a shark launched a “sustained and prolonged attack,” New South Wales (NSW) police said in a statement. Police said a bystander applied a tourniquet before paramedics transferred the surfer to Port Macquarie Hospital in critical condition. “[He is in] a serious condition with life threatening injuries, sustained from the lower leg injuries, and also significant blood loss,” NSW Police Chief Inspector Martin Burke said. Australia ranked behind only the United States in the number of unprovoked shark encounters with humans last year, according to the Florida Museum’s International Shark Attack File. According to the Australian Shark Incident Database, there were 10 shark encounters in New South Wales in 2022, resulting in seven injuries and one death.
Persons: Martin Burke, Organizations: CNN, 9News, Police, Port Macquarie Hospital, ” NSW Police, Port Macquarie, Facebook, Department of Primary Industries, Fisheries, Life, NSW, Australia, Florida, Australian, Incident Locations: Lighthouse Beach, Port Macquarie, New South Wales, NSW, United States
In the latest Equity Talk, she shares how she's overcoming biases in the VC and biotech fields. Verge Genomics works with data derived from brains and spinal cords donated by people after they die. That's really been helpful because they don't necessarily see the same kind of questions. But I think part of that is just showing them that there can be a new way of doing things. I think that's an area where naivete can be a benefit, when you have big technological hurdles to overcome.
Persons: Alice Zhang, Zhang, it's, It's, That's, I've, we're, I'm, who's, There's, Alice, aren't, they're, that's unarguable, Organizations: Genomics, Morning, Verge Genomics, Eff, pharma, Tech
CNN —Gesine Bullock-Prado, the sister of Sandra Bullock, paid tribute Monday to the actress’s longtime partner, photographer Bryan Randall. Randall “passed away peacefully” following a private three-year battle with ALS, his family said in a statement to People magazine. “Bryan chose early to keep his journey with ALS private and those of us who cared for him did our best to honor his request,” his family said in their statement. We share two beautiful children – three children, [Randall’s] older daughter,” Bullock said. “It’s the best thing ever.”Bullock is mother to a 13-year-old son, Louis, and a 10-year-old daughter, Laila.
Persons: CNN — Gesine Bullock, Sandra Bullock, Bryan Randall, Randall “, Bullock, Prado, Randall, “ I’m, Bry, Gesine Bullock, Emma McIntyre, , Bryan, ” Randall, “ Bryan, ” Bullock, , Louis, Laila, Skylar Organizations: CNN, Prado, ALS, Los Angeles, Regency Village Theatre, ALS Association, Massachusetts General Hospital Locations: Los Angeles
Biogen on Tuesday said it expects to cut approximately 1,000 jobs, or about 11% of its workforce, to save costs as the biotech company prepares to launch its newly approved Alzheimer's drug Leqembi. It's the latest round of layoffs after Biogen slashed nearly 900 jobs last year. The larger plan is expected to generate approximately $1 billion in gross operating expense savings by 2025, according to Biogen. About $300 million of those savings will be reinvested into product launches and R&D programs. "There's a need, obviously, to have a strong investment in our new product launches.
Persons: Chris Viehbacher, Wells, Mohit Bansal
Goldman Sachs initiates Amylyx Pharmaceuticals as buy Goldman said it sees an attractive entry point for shares of the biotech company. " Goldman Sachs reiterates Nvidia as buy Goldman said it's standing by its buy rating on Nvidia and that it likes stocks with "room for meaningful positive EPS revisions." UBS downgrades Tesla to neutral from buy UBS said in its downgrade of Tesla that strong growth is already priced in. Goldman Sachs initiates Savers Value Village as buy Goldman said the thrift store operator is a share gainer. Goldman Sachs reiterates ServiceNow as buy Goldman said it sees more upside in shares of ServiceNow as the stock remains a key beneficiary.
Persons: Piper downgrades Estee Lauder, Piper, Baird, Goldman Sachs, Goldman, Wells, Evercore, it's, Stifel, Lam, Tesla, Moffett, Rosenblatt, Raymond James, Becton Dickinson, SLB, Horton, BTIG, Needham, ServiceNow Organizations: Express, Netflix, Amylyx Pharmaceuticals, Bank of America, NTR, RBC, Research, Nvidia, MU, UBS, Semiconductor, Deutsche Bank, Apple, Deutsche, Mac, Med Tech, Schlumberger, Disney, DIS, American Express Locations: China, underperform, ServiceNow
Goldman upgrades this biotech, sees the shares doubling
  + stars: | 2023-07-24 | by ( Alex Harring | ) www.cnbc.com   time to read: +2 min
It's a good time to buy into beat-down Amylyx Pharmaceuticals as investors could be underestimating one of its trials, according to Goldman Sachs. Analyst Corinne Jenkins upgraded the pharmaceutical stock to buy from neutral and increased her price target by $4 to $49. Her new price target implies shares can surge 117% from Friday's close. But investors have been concerned about the stock because of low expectations going into the phase 3 Phoenix study for Relyvrio. But Jenkins also said the approval would likely be a positive catalyst for the beat-down stock.
Persons: Goldman Sachs, Corinne Jenkins, Jenkins, Lou Gehrig's, — CNBC's Michael Bloom Organizations: Pharmaceuticals, PHOENIX Locations: Friday's, U.S
An expansion of the criteria for medically assisted death that comes into force in March 2024 will allow Canadians like Pauli, whose sole underlying condition is mental illness, to choose medically assisted death. In 2021, the most recent year available, 10,064 people died through medically assisted death, about 3.3% of deaths in Canada that year. Dembo served on an expert panel on assisted death and mental illness that presented a report to Canada's parliament last year. loadingThe reported cases of people resorting to medically assisted death in part due to lack of supports are "tragic," Lametti said. "It does in one sense [represent a slippery slope], doesn't it, because it started off with terminal illness and it's ended up with non-terminal illness and mental illness."
Persons: Lisa Pauli, Pauli, I've, David Lametti, Lametti, It's, Marie, Claude Lacasse, Georges L'Esperance, Sarah Dobec, Justine Dembo, Dembo, She's, Mary Heatley, , Heatley, Sonu Gaind, Michelle Hewitt, Hewitt, Sean Tagert, Lou Gehrig's, Tagert's, Sean, Charles Falconer, it's, Anna Mehler Paperny, Denny Thomas, Suzanne Goldenberg Organizations: TORONTO, Reuters, Health, Quebec Association for, Canada, Health Sciences Centre, Labour, Thomson Locations: Canada, Netherlands, Belgium, Provinces, Quebec, British Columbia, Ontario, Health Canada, Canadian, Britain
He was standing in a busy operating room in West Virginia, waiting for a surgeon to place Precision Neuroscience's neural implant system onto a conscious patient's brain for the first time. In seconds, a real-time, high-resolution rendering of the patient's brain activity washed over a screen. According to Precision, the system had provided the highest resolution picture of human thought ever recorded. The company's flagship BCI system, the Layer 7 Cortical Interface, is an electrode array resembling a piece of scotch tape. Since the technology worked as expected, future studies will explore further applications in clinical and behavioral contexts, Mermel said.
Persons: Craig Mermel, Mermel, Elon, Blackrock Neurotech Organizations: Precision, CNBC, Neuralink, Neuroscience, BCI, Blackrock Locations: West Virginia, Paradromics
Neuralink, the neurotech startup co-founded by Elon Musk, announced Thursday it has received approval from the Food and Drug Administration to conduct its first in-human clinical study. A BCI is a system that deciphers brain signals and translates them into commands for external technologies. But receiving FDA approval for a commercial medical device is no small task — it requires companies to successfully conduct several extremely thorough rounds of testing and data safety collection. But by receiving the go-ahead for a study with human patients, Neuralink is one step closer to market. The FDA's approval for an in-human study is a significant win for Neuralink after a series of recent hurdles at the company.
That includes "Personal Voice," which will replicate your voice through AI in 15 minutes. If you have an iPhone or iPad, you'll soon be able to hear it speak in your own voice, Apple announced Tuesday. The Personal Voice feature in use. It's not the first time Apple has ventured into the AI voice market, as iPhone users will be familiar with Siri. It's not clear exactly when Personal Voice will be available, but Apple says it'll be before the end of the year.
The healthcare sector outperformed in Europe, India and China last month, according to Citi, which named its top picks worldwide. It gave Amylyx a price target of $53, giving it upside of around 88% from current levels. It gave Beam a price target of $60, implying upside of around 67%. Other European picks from Citi include Swiss healthcare company Roche and British pharma and biotech firm AstraZeneca . Asia stocks In Asia, Citi named Japanese pharmaceutical company Daiichi Sankyo , South Korean biotech firm Samsung Biologics and China's Wuxi Biologics as top picks.
CNN —Apple on Tuesday announced a series of new accessibility tools for the iPhone and iPad, including a feature that promises to replicate a user’s voice for phone calls after only 15 minutes of training. With an upcoming tool called Personal Voice, users will be able to read text prompts to record audio and have the technology learn their voice. A related feature called Live Speech will then use the “synthesized voice” to read the user’s typed text aloud during phone calls, FaceTime conversations and in-person conversations. In the blog post, Apple said the Personal Voice feature uses “on-device machine learning to keep users’ information private and secure.”Other tech companies have experimented with using AI to replicate a voice. In addition to the voice features, Apple announced Assistive Access, which combines some of the most popular iOS apps, such as FaceTime, Messages, Camera, Photos, Music and Phone, into one Calls app.
Check out the companies making headlines in premarket trading. AMD — The semiconductor stock fell more than 7% in premarket trading after quarterly results a day earlier. PacWest's shares fell 4.6% in premarket trading after sliding nearly 28% on Tuesday. Biogen reported earnings last week, notching an adjusted $3.40 per share while analysts polled by StreetAccount forecasted $3.28. The online dating company reported first-quarter earnings that topped analysts estimates from Refinitiv after the bell Tuesday.
The Food and Drug Administration on Tuesday granted accelerated approval for Biogen 's drug tofersen, which treats a rare and aggressive form of the disease known as ALS. Accelerated approval is an FDA designation that clears drugs faster if they fill an unmet medical need for serious conditions. If a subsequent trial confirms those benefits, the FDA can grant traditional approval for the drug. An independent panel of advisors to the FDA last month similarly voted that tofersen's effect on neurofilament could produce a clinical benefit in ALS patients. Stephanie Fradette, Biogen's head of ALS development, said those SOD1 protein levels are "indirect evidence" that tofersen targets the rare form of ALS.
Biogen isn't worried about competing with Eli Lilly as they both attempt to bring an Alzheimer's drug to the market, Biogen's CEO said Tuesday. Researchers argue that the accumulation of amyloid plaque is a crucial first step toward the cognitive decline observed in Alzheimer's disease. Eli Lilly didn't immediately respond to a request for comment. He said that will likely require Eli Lilly and Biogen to roll out maintenance doses that will keep plaque levels low. Biogen is banking on the success of its drug leqembi after the disastrous approval and rollout of its old Alzheimer's drug aduhelm last year.
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